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排序方式: 共有130条查询结果,搜索用时 15 毫秒
121.
Nan Yu Hans-Wilhelm Nützmann James T. MacDonald Ben Moore Ben Field Souha Berriri Martin Trick Susan J. Rosser S. Vinod Kumar Paul S. Freemont Anne Osbourn 《Nucleic acids research》2016,44(5):2255-2265
Plants are a tremendous source of diverse chemicals, including many natural product-derived drugs. It has recently become apparent that the genes for the biosynthesis of numerous different types of plant natural products are organized as metabolic gene clusters, thereby unveiling a highly unusual form of plant genome architecture and offering novel avenues for discovery and exploitation of plant specialized metabolism. Here we show that these clustered pathways are characterized by distinct chromatin signatures of histone 3 lysine trimethylation (H3K27me3) and histone 2 variant H2A.Z, associated with cluster repression and activation, respectively, and represent discrete windows of co-regulation in the genome. We further demonstrate that knowledge of these chromatin signatures along with chromatin mutants can be used to mine genomes for cluster discovery. The roles of H3K27me3 and H2A.Z in repression and activation of single genes in plants are well known. However, our discovery of highly localized operon-like co-regulated regions of chromatin modification is unprecedented in plants. Our findings raise intriguing parallels with groups of physically linked multi-gene complexes in animals and with clustered pathways for specialized metabolism in filamentous fungi. 相似文献
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Functional implications of the Klenow fragment structure 总被引:1,自引:0,他引:1
T A Steitz P S Freemont D L Ollis C M Joyce J M Grindley 《Biochemical Society transactions》1986,14(2):205-207
126.
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites. 总被引:14,自引:1,他引:13 下载免费PDF全文
M A Gorman S Morera D G Rothwell E de La Fortelle C D Mol J A Tainer I D Hickson P S Freemont 《The EMBO journal》1997,16(21):6548-6558
The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2 A resolution. The enzyme consists of two symmetrically related domains of similar topology and has significant structural similarity to both bovine DNase I and its Escherichia coli homologue exonuclease III (EXOIII). A structural comparison of these enzymes reveals three loop regions specific to HAP1 and EXOIII. These loop regions apparently act in DNA abasic site (AP) recognition and cleavage since DNase I, which lacks these loops, correspondingly lacks AP site specificity. The HAP1 structure furthermore suggests a mechanism for AP site binding which involves the recognition of the deoxyribose moiety in an extrahelical conformation, rather than a 'flipped-out' base opposite the AP site. 相似文献
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A novel zinc finger coiled-coil domain in a family of nuclear proteins. 总被引:27,自引:0,他引:27
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A novel cysteine-rich sequence motif 总被引:76,自引:0,他引:76
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